Bio-inspired biofabrication in cardiovascular tissue engineering
Valvular heart disease caused by stenosis, regurgitation or congenital defects are the worldwide third leading contributor to cardiovascular disease resulting in more than 5 million deaths annually. Tissue Engineered Heart Valves (TEHVs) aim to overcome the disadvantages of current heart valve prosthesis by providing an alternative mechanically stable valve that also supports tissue growth and remodelling. Additionally, heart valves are characterized to be highly flexible yet tough, and exhibit complex deformation characteristics such as nonlinearity, anisotropy and viscoelasticity, which are at best only partially recapitulated in scaffolds for heart valve tissue engineering (HVTE). Thus, improved strategies and fabrication technologies have to be established in order to facilitate their translation from bench to bedside.
To address this challenge we have employed a biologically-inspired design and biofabrication strategy aiming to embrace mechanical, structural and geometrical complexities of a native heart valve. We exploited the unique capabilities of melt electrowriting (MEW) to create functional scaffolds with highly controlled fibrous microarchitectures mimicking the wavy nature of the collagen fibers and their load-dependent recruitment. MEW is a novel biofabrication technology which combines principles of both electrospinning and additive biomanufacturing to produce highly organised fibrous constructs with micrometric features. The convergence of MEW and a biomimetic design approach enables a new paradigm for the manufacture of functional scaffolds with highly controlled microarchitectures, biocompatibility, and stringent nonlinear and anisotropic mechanical properties required for HVTE.
Date and Time
Location
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Registration
- Date: 27 Mar 2019
- Time: 02:00 PM to 03:00 PM
- All times are (GMT+10:00) Australia/Queensland
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- Gardens Point Campus
- Queensland University of Technology (QUT)
- Brisbane, Queensland
- Australia 4001
- Building: O Block
- Room Number: O-520
- Contact Event Host
- Co-sponsored by IEEE QUT Student Branch
- Starts 19 March 2019 09:06 AM
- Ends 27 March 2019 11:00 AM
- All times are (GMT+10:00) Australia/Queensland
- No Admission Charge
Speakers
Mr. Navid Toosisaidy of Queensland University of Technology
Biography:
After completing a bachelors in mechanical engineering with first class honours from Taylors University, Malaysia (2017), Navid Toosi Saidy started his PhD in regenerative medicine group at the institute of health and biomedical innovation, QUT led by D/Prof Dietmar Hutmacher. His research project involves the convergence of advanced biomaterials and additive manufacturing techniques to fabricate scaffolds for cardiovascular tissue engineering applications. In addition, Navid spent 8 months as a visiting scientist at the Center for Biohybrid Medical systems, Aachen, Germany where he has been involved with characterising heart valves in costume-made cardiovascular bioreactor systems.
Agenda
14:00-14:10 Welcome and introduction
14:10-14:40 Technical presentation
14:40-14:50 Q&A
14:50-13:00 Light refreshments