BEGIN:VCALENDAR VERSION:2.0 PRODID:IEEE vTools.Events//EN CALSCALE:GREGORIAN BEGIN:VTIMEZONE TZID:Australia/Sydney BEGIN:DAYLIGHT DTSTART:20181007T030000 TZOFFSETFROM:+1000 TZOFFSETTO:+1100 RRULE:FREQ=YEARLY;BYDAY=1SU;BYMONTH=10 TZNAME:AEDT END:DAYLIGHT BEGIN:STANDARD DTSTART:20190407T020000 TZOFFSETFROM:+1100 TZOFFSETTO:+1000 RRULE:FREQ=YEARLY;BYDAY=1SU;BYMONTH=4 TZNAME:AEST END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTAMP:20190911T034403Z UID:14E247AB-D7F6-4494-A56C-0740851B7A38 DTSTART;TZID=Australia/Sydney:20190225T130000 DTEND;TZID=Australia/Sydney:20190225T140000 DESCRIPTION:Title: New Forms of Microscopy Enabled by Nanostructured Surfac es\n\n== Join us on 25 Feb 2019 at UTS to hear Prof. Cunningham talk about Photonic Resonator Outcoupler Microscopy. Free registration ==\n\nSince t he advent of optical microscopy\, a flat glass microscope slide has been t he standard surface upon which tissues\, cells\, and biomolecules are atta ched for observation. Recently\, we have utilized the optically resonant p roperties of nanostructured photonic crystal (PC) surfaces to enable sever al new microscopy modalities where the nanostructure provides new forms of contrast for a wide variety of compelling applications. By designing PC s urfaces with resonances that match the excitation and emission spectra of photon emitters such as fluorophores and quantum dots\, PC enhanced fluore scence (PCEF) microscopy reduces the detection limits of any surface-based fluorescence assay. By generating spatial images of the PC resonant refle ction intensity\, we can selectively and dynamically visualize the cell-ex tracellular matrix interface during processes that include stem cell diffe rentiation\, cancer cell response to drugs\, and chemotaxis – including the ability to observe the formation and evolution of cell membrane focal adhesion sites.\n\nWe call this approach Photonic Resonator Outcoupler Mic roscopy (PROM)\, as we observe highly localized outcoupling of light from the PC that occurs due to scattering by dense regions in the cell membrane . Further\, by utilizing metallic nanoparticle tags with plasmon resonance s that match the PC resonance\, we obtain highly efficient coupling of lig ht into nanometer-scale electromagnetic hotspots\, that is accompanied by\ nhighly localized “quenching” of the PC reflection efficiency\, which we are using for digital-resolution detection of miRNA biomarkers for canc er with 100 aM limits of detection\, using an approach called Photonic Res onator Absorption Microscopy (PRAM). The seminar will describe the physica l principles\, nanostructure design/fabrication\, instrumentation\, and ap plications for nanostructure-enabled microscopy for disease diagnostics\, personalized medicine\, and life science research.\n\nSpeaker(s): Prof. Br ian T. Cunningham\, \n\nRoom: Room 11.06.408\, Bldg: Building 11\, UTS Cit y Campus\, Room 11.06.408\, Level 6\, Building 11\, 81 Broadway\, Ultimo\, New South Wales\, Australia\, 2007 LOCATION:Room: Room 11.06.408\, Bldg: Building 11\, UTS City Campus\, Room 11.06.408\, Level 6\, Building 11\, 81 Broadway\, Ultimo\, New South Wales \, Australia\, 2007 ORGANIZER:yang.yang-1@uts.edu.au SEQUENCE:6 SUMMARY:Distinguished Lecture: New Forms of Microscopy Enabled by Nanostruc tured Surfaces URL;VALUE=URI:https://events.vtools.ieee.org/m/192087 X-ALT-DESC:Description: <br /><p><strong>Title: New Forms of Microscopy Ena bled by Nanostructured Surfaces</strong></p>\n<p>== Join us on 25 Feb 2019 at UTS to hear Prof. Cunningham talk about&nbsp\;Photonic Resonator Outco upler Microscopy. Free registration ==</p>\n<p>Since the advent of optical microscopy\, a flat glass microscope slide has been the standard surface upon which tissues\, cells\, and biomolecules are attached for observation . Recently\, we have utilized the optically resonant properties of nanostr uctured photonic crystal (PC) surfaces to enable several new microscopy mo dalities where the nanostructure provides new forms of contrast for a wide variety of compelling applications. By designing PC surfaces with resonan ces that match the excitation and emission spectra of photon emitters such as fluorophores and quantum dots\, PC enhanced fluorescence (PCEF) micros copy reduces the detection limits of any surface-based fluorescence assay. By generating spatial images of the PC resonant reflection intensity\, we can selectively and dynamically visualize the cell-extracellular matrix i nterface during processes that include stem cell differentiation\, cancer cell response to drugs\, and chemotaxis &ndash\; including the ability to observe the formation and evolution of cell membrane focal adhesion sites. </p>\n<p>We call this approach Photonic Resonator Outcoupler Microscopy (P ROM)\, as we observe highly localized outcoupling of light from the PC tha t occurs due to scattering by dense regions in the cell membrane. Further\ , by utilizing metallic nanoparticle tags with plasmon resonances that mat ch the PC resonance\, we obtain highly efficient coupling of light into na nometer-scale electromagnetic hotspots\, that is accompanied by<br />highl y localized &ldquo\;quenching&rdquo\; of the PC reflection efficiency\, wh ich we are using for digital-resolution detection of miRNA biomarkers for cancer with 100 aM limits of detection\, using an approach called Photonic Resonator Absorption Microscopy (PRAM). The seminar will describe the phy sical principles\, nanostructure design/fabrication\, instrumentation\, an d applications for nanostructure-enabled microscopy for disease diagnostic s\, personalized medicine\, and life science research.</p> END:VEVENT END:VCALENDAR