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DTSTART;TZID=Europe/Zurich:20190702T130000
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DESCRIPTION:Seminar title: CMOS Microelectronics for DNA detection using Io
 n-Sensitive Field Effect Transistors\n\nIn the last decade\, we have seen 
 a convergence of microelectronics into the world of healthcare providing n
 ovel solutions for early detection\, diagnosis and therapy of disease. Thi
 s has been made possible due to the emergence of CMOS technology\, allowin
 g fabrication of advanced systems with complete integration of sensors\, i
 nstrumentation and processing\, enabling design of miniaturised medical de
 vices which operate with low-power. This has been specifically beneficial 
 for the application areas of DNA based diagnostics and full genome sequenc
 ing\, where the implementation of chemical sensors known as Ion-Sensitive 
 Field Effect Transistors (ISFETs) directly in CMOS has enabled the design 
 of large-scale arrays of millions of sensors that can conduct in-parallel 
 detection of DNA. Furthermore\, the scaling of CMOS with Moore’s law and
  the integration capability with microfluidics has enabled commercial effo
 rts to make full genome sequencing affordable and therefore deployable in 
 hospitals and research labs.\n\nIn this talk\, I present how my lab is adv
 ancing the areas of DNA detection and rapid diagnostics through the design
  of CMOS based Lab-on-Chip systems using ISFETs. I will first introduce th
 e fundamentals and physical properties of DNA as a target molecule and how
  it can be detected using different modalities through the use of CMOS tec
 hnology. I will then present methods of design of ISFET sensors and instru
 mentation in CMOS\, in addition to the challenges and limitations that exi
 st for fabrication\, providing solutions to allow design of large-scale IS
 FET arrays for real-time DNA amplification and detection systems. I will c
 onclude with the presentation of state-of-the-art CMOS systems that are cu
 rrently being used for genomics and point-of-care diagnostics\, and the re
 sults of our latest fabricated multi-sensor CMOS platform for rapid screen
 ing of infectious disease and management of antimicrobial resistance.\n\nS
 peaker(s): Dr. Pantelis Georgiou\, \n\nRoom: E7\, Bldg: ETZ\, ETH Zurich\,
  Gloriastrasse 35\, Zurich\, Switzerland\, Switzerland\, 8092 Zürich
LOCATION:Room: E7\, Bldg: ETZ\, ETH Zurich\, Gloriastrasse 35\, Zurich\, Sw
 itzerland\, Switzerland\, 8092 Zürich
ORGANIZER:shih@ini.phys.ethz.ch
SEQUENCE:1
SUMMARY:IEEE Swiss CASS Talk by Dr. Pantelis Georgiou
URL;VALUE=URI:https://events.vtools.ieee.org/m/199286
X-ALT-DESC:Description: <br /><p><u>Seminar title: <strong>CMOS Microelectr
 onics for DNA detection using Ion-Sensitive Field Effect Transistors</stro
 ng></u></p>\n<p>In the last decade\, we have seen a convergence of microel
 ectronics into the world of healthcare providing novel solutions for early
  detection\, diagnosis and therapy of disease. This has been made possible
  due to the emergence of CMOS technology\, allowing fabrication of advance
 d systems with complete integration of sensors\, instrumentation and proce
 ssing\, enabling design of miniaturised medical devices which operate with
  low-power. This has been specifically beneficial for the application area
 s of DNA based diagnostics and full genome sequencing\, where the implemen
 tation of chemical sensors known as Ion-Sensitive Field Effect Transistors
  (ISFETs) directly in CMOS has enabled the design of large-scale arrays of
  millions of sensors that can conduct in-parallel detection of DNA. Furthe
 rmore\, the scaling of CMOS with Moore&rsquo\;s law and the integration ca
 pability with microfluidics has enabled commercial efforts to make full ge
 nome sequencing affordable and therefore deployable in hospitals and resea
 rch labs.</p>\n<p>&nbsp\;</p>\n<p>In this talk\, I present how my lab is a
 dvancing the areas of DNA detection and rapid diagnostics through the desi
 gn of CMOS based Lab-on-Chip systems using ISFETs. I will first introduce 
 the fundamentals and physical properties of DNA as a target molecule and h
 ow it can be detected using different modalities through the use of CMOS t
 echnology. I will then present methods of design of ISFET sensors and inst
 rumentation in CMOS\, in addition to the challenges and limitations that e
 xist for fabrication\, providing solutions to allow design of large-scale 
 ISFET arrays for real-time DNA amplification and detection systems. I will
  conclude with the presentation of state-of-the-art CMOS systems that are 
 currently being used for genomics and point-of-care diagnostics\, and the 
 results of our latest fabricated multi-sensor CMOS platform for rapid scre
 ening of infectious disease and management of antimicrobial resistance.</p
 >
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