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VERSION:2.0
PRODID:IEEE vTools.Events//EN
CALSCALE:GREGORIAN
BEGIN:VTIMEZONE
TZID:Asia/Hong_Kong
BEGIN:STANDARD
DTSTART:19791021T023000
TZOFFSETFROM:+0900
TZOFFSETTO:+0800
TZNAME:HKT
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BEGIN:VEVENT
DTSTAMP:20191101T085148Z
UID:FEFC1A54-9DA1-49BA-86AA-FBE4DA9363CF
DTSTART;TZID=Asia/Hong_Kong:20190410T120000
DTEND;TZID=Asia/Hong_Kong:20190410T133000
DESCRIPTION:The\ncentral nervous system ( consumes very high levels of\nene
 rgy Thus\, altered energy metabolism is associated with\nserious neuronal 
 dysfunction\, neurodevelopmental defect\, and\nneurodegeneration in certai
 n neurological disorders as well as it\ncan have an effect on the malignan
 t progression of CNS tumors\,\nincluding glioma and medullablastoma Glucos
 e is the essential\nenergy substrate for the CNS Nonetheless\, in certain 
 conditions\nsuch as oxygen and glucose deficiency\, during the neonatal\np
 eriod\, or under the progression of brain cancer\,\nmonocarboxylates inclu
 ding lactate and ketone body\, are\nconsumed by the CNS as energy fuels an
 d bio precursors\nMonocarboxylates\nare co transported along with protons 
 across\nthe plasma membrane by monocarboxylate transporters 1 to 4\n(MCTs 
 1 4 The in vivo distribution and role of MCT 1 a major CNS\nlactate transp
 orter\, has been identified by us and other\ncolleagues\nWe\nare now inves
 tigating the function of MCT 1 and its ancillary\nprotein\, CD 147 in neur
 odevelopment and glioma progression via\nusing both animal models in vivo 
 and cell models in vitro We are\nalso investigating the inhibitors for MCT
  1 /CD 147 for the potential\ntherapeutics in neurodevelopment disorders a
 nd glioma For\nexample\, we have found that glioma cells are susceptible t
 o the\ngene silencing and chemical inhibition for MCT 1 and CD 147\nRecent
 ly\, we have also found the crucial role of MCT 1 and CD 147\nin glioma pr
 ogression via exosomes\, which can be precisely\ndetected by LSPR and AFM 
 biosensors\n\nCo-sponsored by: IEEE EMB HK-Macau Joint Chapter\n\nSpeaker(
 s): Dr . Youngjin Lee\, \n\nRoom: 306\, Bldg: PQ\, The Hong Kong Polytechn
 ic University\, HK\, Hong Kong\, Hong Kong
LOCATION:Room: 306\, Bldg: PQ\, The Hong Kong Polytechnic University\, HK\,
  Hong Kong\, Hong Kong
ORGANIZER:embs.hk.macau@gmail.com
SEQUENCE:0
SUMMARY:Study of MCT1 and CD147 in CNS Health and Disease \; Biosensing to 
 Therapeutics
URL;VALUE=URI:https://events.vtools.ieee.org/m/209219
X-ALT-DESC:Description: <br /><p>The<br />central nervous system ( consumes
  very high levels of<br />energy Thus\, altered energy metabolism is assoc
 iated with<br />serious neuronal dysfunction\, neurodevelopmental defect\,
  and<br />neurodegeneration in certain neurological disorders as well as i
 t<br />can have an effect on the malignant progression of CNS tumors\,<br 
 />including glioma and medullablastoma Glucose is the essential<br />energ
 y substrate for the CNS Nonetheless\, in certain conditions<br />such as o
 xygen and glucose deficiency\, during the neonatal<br />period\, or under 
 the progression of brain cancer\,<br />monocarboxylates including lactate 
 and ketone body\, are<br />consumed by the CNS as energy fuels and bio pre
 cursors<br />Monocarboxylates<br />are co transported along with protons a
 cross<br />the plasma membrane by monocarboxylate transporters 1 to 4<br /
 >(MCTs 1 4 The in vivo distribution and role of MCT 1 a major CNS<br />lac
 tate transporter\, has been identified by us and other<br />colleagues<br 
 />We<br />are now investigating the function of MCT 1 and its ancillary<br
  />protein\, CD 147 in neurodevelopment and glioma progression via<br />us
 ing both animal models in vivo and cell models in vitro We are<br />also i
 nvestigating the inhibitors for MCT 1 /CD 147 for the potential<br />thera
 peutics in neurodevelopment disorders and glioma For<br />example\, we hav
 e found that glioma cells are susceptible to the<br />gene silencing and c
 hemical inhibition for MCT 1 and CD 147<br />Recently\, we have also found
  the crucial role of MCT 1 and CD 147<br />in glioma progression via exoso
 mes\, which can be precisely<br />detected by LSPR and AFM biosensors</p>
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