BEGIN:VCALENDAR
VERSION:2.0
PRODID:IEEE vTools.Events//EN
CALSCALE:GREGORIAN
BEGIN:VTIMEZONE
TZID:US/Central
BEGIN:DAYLIGHT
DTSTART:20210314T030000
TZOFFSETFROM:-0600
TZOFFSETTO:-0500
RRULE:FREQ=YEARLY;BYDAY=2SU;BYMONTH=3
TZNAME:CDT
END:DAYLIGHT
BEGIN:STANDARD
DTSTART:20201101T010000
TZOFFSETFROM:-0500
TZOFFSETTO:-0600
RRULE:FREQ=YEARLY;BYDAY=1SU;BYMONTH=11
TZNAME:CST
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTAMP:20201208T154233Z
UID:A9F38C56-5704-4543-B0A1-3CFD95C1CCBD
DTSTART;TZID=US/Central:20201120T190000
DTEND;TZID=US/Central:20201120T200000
DESCRIPTION:Geometrically confined magnetic particles due to their unique r
 esponse to external magnetic fields find a variety of applications\, inclu
 ding magnetic guidance\, heat and drug delivery\, magneto-mechanical actua
 tion\, and contrast enhancement. Highly sensitive detection and imaging te
 chniques based on the nonlinear properties of nanomagnets were recently pr
 oposed as innovative strong-translational potential methods applicable in 
 complex\, often opaque\, biological systems. Here we report on the signifi
 cant enhancement of the detection capability using optical-lithography-def
 ined\, ferromagnetic iron–nickel alloy disk-shaped particles. We show th
 at an irreversible transition between strongly non-collinear (vortex) and 
 single domain states\, driven by an alternating magnetic field\, translate
 s into a nonlinear magnetic response that enables ultrasensitive detection
  of these particles. The record sensitivity of ∼3.5 × 10−9 emu\, whic
 h is equivalent to ∼39 pg of magnetic material is demonstrated at room t
 emperature for arrays of patterned disks. We also show that unbound disks 
 suspended in the aqueous buffer can be successfully detected and quantifie
 d in real-time when administered into a live animal allowing for tracing o
 f their biodistribution. The use of nanoscale ferromagnetic particles with
  engineered nonlinear properties opens prospects for further enhancing the
  sensitivity\, scalability\, and tunability of noise-free magnetic tag det
 ection in high-background environments for various applications spanning f
 rom biosensing and medical imaging to anti-counterfeiting technologies.\n\
 nSpeaker(s): Dr. Valentine Novosad\, \n\nVirtual: https://events.vtools.ie
 ee.org/m/244475
LOCATION:Virtual: https://events.vtools.ieee.org/m/244475
ORGANIZER:novosad@ieee.org
SEQUENCE:2
SUMMARY:Ultrasensitive detection enabled by nonlinear magnetization of nano
 magnetic labels
URL;VALUE=URI:https://events.vtools.ieee.org/m/244475
X-ALT-DESC:Description: <br /><div class="capsule__text">\n<p>Geometrically
  confined magnetic particles due to their unique response to external magn
 etic fields find a variety of applications\, including magnetic guidance\,
  heat and drug delivery\, magneto-mechanical actuation\, and contrast enha
 ncement. Highly sensitive detection and imaging techniques based on the no
 nlinear properties of nanomagnets were recently proposed as innovative str
 ong-translational potential methods applicable in complex\, often opaque\,
  biological systems. Here we report on the significant enhancement of the 
 detection capability using optical-lithography-defined\, ferromagnetic iro
 n&ndash\;nickel alloy disk-shaped particles. We show that an irreversible 
 transition between strongly non-collinear (vortex) and single domain state
 s\, driven by an alternating magnetic field\, translates into a nonlinear 
 magnetic response that enables ultrasensitive detection of these particles
 . The record sensitivity of &sim\;3.5 &times\; 10<small><sup>&minus\;9</su
 p></small> emu\, which is equivalent to &sim\;39 pg of magnetic material i
 s demonstrated at room temperature for arrays of patterned disks. We also 
 show that unbound disks suspended in the aqueous buffer can be successfull
 y detected and quantified in real-time when administered into a live anima
 l allowing for tracing of their biodistribution. The use of nanoscale ferr
 omagnetic particles with engineered nonlinear properties opens prospects f
 or further enhancing the sensitivity\, scalability\, and tunability of noi
 se-free magnetic tag detection in high-background environments for various
  applications spanning from biosensing and medical imaging to anti-counter
 feiting technologies.</p>\n</div>
END:VEVENT
END:VCALENDAR