BEGIN:VCALENDAR VERSION:2.0 PRODID:IEEE vTools.Events//EN CALSCALE:GREGORIAN BEGIN:VTIMEZONE TZID:America/Denver BEGIN:DAYLIGHT DTSTART:20170312T030000 TZOFFSETFROM:-0700 TZOFFSETTO:-0600 RRULE:FREQ=YEARLY;BYDAY=2SU;BYMONTH=3 TZNAME:MDT END:DAYLIGHT BEGIN:STANDARD DTSTART:20171105T010000 TZOFFSETFROM:-0600 TZOFFSETTO:-0700 RRULE:FREQ=YEARLY;BYDAY=1SU;BYMONTH=11 TZNAME:MST END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTAMP:20170810T000108Z UID:9847D61E-7D5E-11E7-8752-0050568D2FB3 DTSTART;TZID=America/Denver:20170828T121500 DTEND;TZID=America/Denver:20170828T131500 DESCRIPTION:The ED/CAS Chapter of the Pikes Peak Section of the IEEE is ple ased to invite you to a talk given by Dr. Taylor D. Webb on Focusing Ultra sound Through the Skull: The Promise and Challenge of Transcranial Focused Ultrasound.\n\nThe Transcranial focused ultrasound (FUS) is a class of ul trasound techniques with the potential to provide a variety of new non-inv asive treatment options for pathologies ranging from cancer to depression. At high energies\, FUS can destroy diseased tissue through thermal ablati on\, a technique that was recently approved by the FDA to treat essential tremor. At lower energies\, FUS can reversibly open the blood brain barrie r for the delivery of chemotherapeutic agents to tumors and it can modulat e neural activity\, suggesting the possibility of using FUS to treat menta l illness and study neural function.\n\nHowever\, delivery of the acoustic energy to the desired location of the brain is difficult because heteroge neity in the acoustic properties of the skull causes alterations to the si ze\, shape\, and location of the beam’s focus. Compensating for these di stortions requires knowledge of the acoustic velocity in the patient’s s kull. Clinically\, the velocity is estimated using a CT scan of the patien t\, but there is disagreement about the correct method for obtaining the a coustic velocity from the CT image and\, because FUS procedures are often performed under MR guidance\, there is interest in estimating the velocity with MRI.\n\nWe are developing models relating the acoustic velocity of h uman skull bone to CT Hounsfield Units (HU) and two different parameters m easured with ultra short echo time (UTE) MRI. These models allow us to est imate the acoustic velocity in individual patient skulls using either a CT or MR image. They are generated using measurements from 100 fragments tak en from two ex-vivo human skulls. Our results show that velocity is strong ly correlated with both HU and the measured MR parameters. These models wi ll improve the accuracy of CT based velocity estimates and\, by allowing t he use of MRI instead of CT\, eliminate the need for ionizing radiation\, leading to improved treatment efficacy and more widespread application of FUS.\n\nCo-sponsored by: Dr. T.S. Kalkur\n\nSpeaker(s): Dr. Taylor Webb\, \, Dr. Taylor Webb\, \n\nRoom: ENG 105\, Bldg: Engineering Building\, Univ ersity of Colorado at Colorado Springs\, 1420 Austin Bluffs Parkway\, Colo rado Springs\, Colorado\, United States\, 80918 LOCATION:Room: ENG 105\, Bldg: Engineering Building\, University of Colorad o at Colorado Springs\, 1420 Austin Bluffs Parkway\, Colorado Springs\, Co lorado\, United States\, 80918 ORGANIZER:tkalkur@uccs.edu SEQUENCE:1 SUMMARY:Focusing Ultrasound Through the Skull: The Promise and Challenge of Transcranial Focused Ultrasound URL;VALUE=URI:https://events.vtools.ieee.org/m/46519 X-ALT-DESC:Description: <br /><p><strong>The ED/CAS Chapter of the Pikes Pe ak Section of the IEEE is pleased to invite you to a talk given by Dr. Tay lor D. Webb on Focusing Ultrasound Through the Skull: The Promise and Chal lenge of Transcranial Focused Ultrasound.</strong></p>\n<p>The Transcrania l focused ultrasound (FUS) is a class of ultrasound techniques with the po tential to provide a variety of new non-invasive treatment options for pat hologies ranging from cancer to depression. At high energies\, FUS can des troy diseased tissue through thermal ablation\, a technique that was recen tly approved by the FDA to treat essential tremor. At lower energies\, FUS can reversibly open the blood brain barrier for the delivery of chemother apeutic agents to tumors and it can modulate neural activity\, suggesting the possibility of using FUS to treat mental illness and study neural func tion.</p>\n<p>However\, delivery of the acoustic energy to the desired loc ation of the brain is difficult because heterogeneity in the acoustic prop erties of the skull causes alterations to the size\, shape\, and location of the beam&rsquo\;s focus. Compensating for these distortions requires kn owledge of the acoustic velocity in the patient&rsquo\;s skull. Clinically \, the velocity is estimated using a CT scan of the patient\, but there is disagreement about the correct method for obtaining the acoustic velocity from the CT image and\, because FUS procedures are often performed under MR guidance\, there is interest in estimating the velocity with MRI.</p>\n <p>We are developing models relating the acoustic velocity of human skull bone to CT Hounsfield Units (HU) and two different parameters measured wit h ultra short echo time (UTE) MRI. These models allow us to estimate the a coustic velocity in individual patient skulls using either a CT or MR imag e. They are generated using measurements from 100 fragments taken from two ex-vivo human skulls. Our results show that velocity is strongly correlat ed with both HU and the measured MR parameters. These models will improve the accuracy of CT based velocity estimates and\, by allowing the use of M RI instead of CT\, eliminate the need for ionizing radiation\, leading to improved treatment efficacy and more widespread application of FUS.</p> END:VEVENT END:VCALENDAR