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DTSTAMP:20250625T145959Z
UID:7199810A-3209-4458-91DC-E76D90DA2A14
DTSTART;TZID=Asia/Kolkata:20250424T133000
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DESCRIPTION:In the realm of label-free imaging techniques\, coherent Raman 
 imaging (CRI) emerges as a powerful tool\, offering sub-cellular spatial r
 esolution\, molecular-specific contrast\, and addressing the unmet need in
  life sciences for label-free chemically specific imaging by detecting the
  intrinsic vibrational fingerprints of cells and tissues [1].\n\nMultiplex
  stimulated Raman scattering (SRS) microscopy [2]\, combining single-shot 
 detection of broad vibrational spectra and high spectral resolution\, full
 y exploits the innovative potential of CRI tools. State of the art impleme
 ntations of multiplex SRS systems are based on custom and complex solution
 s\, rendering them completely inaccessible to non-specialists in the field
  [2\,3].\n\nHere\, we present a fully engineered Broadband Coherent Raman 
 Platform – CORAL designed to achieve state-of-the-art performance in mul
 tiplex SRS with unprecedented ease of use and long-term reproducibility. C
 ORAL comprises an all-fiber dual-wavelength self-synchronized laser and a 
 detection unit based on a compact multichannel lock-in amplifier\, ensurin
 g shot-noise-limited SRS performance over the entire CH spectrum (2800-310
 0 cm⁻¹)\, parallelizing detection across 38 spectral channels in 2 μs.
  Additionally\, the system is equipped with an epi-detection module for TP
 EF and SHG signals.\n\nMoreover\, CORAL combines a broadband label-free ap
 proach for chemometric analysis of biological specimens with artificial in
 telligence tools\, enabling users to unleash the full power of hyperspectr
 al data. Such a system finds broad application in biomedical sectors where
  traditional exogenous labeling is a limiting factor\, such as in live cel
 l imaging\, metabolomics\, and histopathology.\n\n[1] Zhang\, C. &amp; Cheng\,
  J.-X. Perspective: Coherent Raman scattering microscopy\, the future is b
 right. APL Photonics vol. 3 090901 (2018).\n\n[2] Fu\, D. et al. Quantitat
 ive Chemical Imaging with Multiplex Stimulated Raman Scattering Microscopy
 . Journal of the American Chemical Society vol. 134 3623–3626 (2012).\n\
 n[3] De la Cadena\, A. et al. Broadband stimulated Raman imaging based on 
 multi-channel lock-in detection for spectral histopathology. APL Photonics
  vol. 7 076104 (2022).\n\nSpeaker(s): Dr Matteo Negro\n\nVirtual: https://
 events.vtools.ieee.org/m/482302
LOCATION:Virtual: https://events.vtools.ieee.org/m/482302
ORGANIZER:uttaranb417@gmail.com
SEQUENCE:18
SUMMARY:Advances in broadband coherent Raman microscopy instrumentation: a 
 coherent Raman platform for biomedical imaging
URL;VALUE=URI:https://events.vtools.ieee.org/m/482302
X-ALT-DESC:Description: &lt;br /&gt;&lt;p class=&quot;MsoNormal&quot;&gt;&lt;span lang=&quot;EN-US&quot;&gt;In th
 e realm of label-free imaging techniques\, coherent Raman imaging (CRI) em
 erges as a powerful tool\, offering sub-cellular spatial resolution\, mole
 cular-specific contrast\, and addressing the unmet need in life sciences f
 or label-free chemically specific imaging by detecting the intrinsic vibra
 tional fingerprints of cells and tissues [1].&lt;/span&gt;&lt;/p&gt;\n&lt;p class=&quot;MsoNor
 mal&quot;&gt;&lt;span lang=&quot;EN-US&quot;&gt;Multiplex stimulated Raman scattering (SRS) micros
 copy [2]\, combining single-shot detection of broad vibrational spectra an
 d high spectral resolution\, fully exploits the innovative potential of CR
 I tools. State of the art implementations of multiplex SRS systems are bas
 ed on custom and complex solutions\, rendering them completely inaccessibl
 e to non-specialists in the field [2\,3].&lt;/span&gt;&lt;/p&gt;\n&lt;p class=&quot;MsoNormal&quot;
 &gt;&lt;span lang=&quot;EN-US&quot;&gt;Here\, we present a fully engineered Broadband Coheren
 t Raman Platform &amp;ndash\; CORAL designed to achieve state-of-the-art perfo
 rmance in multiplex SRS with unprecedented ease of use and long-term repro
 ducibility. CORAL comprises an all-fiber dual-wavelength self-synchronized
  laser and a detection unit based on a compact multichannel lock-in amplif
 ier\, ensuring shot-noise-limited SRS performance over the entire CH spect
 rum (2800-3100 cm&lt;/span&gt;&lt;span lang=&quot;EN-US&quot; style=&quot;font-family: &#39;Cambria Ma
 th&#39;\,serif\; mso-bidi-font-family: &#39;Cambria Math&#39;\;&quot;&gt;⁻&lt;/span&gt;&lt;span lang=
 &quot;EN-US&quot; style=&quot;mso-ascii-font-family: Aptos\; mso-hansi-font-family: Aptos
 \; mso-bidi-font-family: Aptos\;&quot;&gt;&amp;sup1\;&lt;/span&gt;&lt;span lang=&quot;EN-US&quot;&gt;)\, par
 allelizing detection across 38 spectral channels in 2 &lt;/span&gt;&lt;span lang=&quot;I
 T&quot; style=&quot;mso-ascii-font-family: Aptos\; mso-hansi-font-family: Aptos\; ms
 o-bidi-font-family: Aptos\; mso-ansi-language: IT\;&quot;&gt;&amp;mu\;&lt;/span&gt;&lt;span lan
 g=&quot;EN-US&quot;&gt;s. Additionally\, the system is equipped with an epi-detection m
 odule for TPEF and SHG signals.&lt;/span&gt;&lt;/p&gt;\n&lt;p class=&quot;MsoNormal&quot;&gt;&lt;span lan
 g=&quot;EN-US&quot;&gt;Moreover\, CORAL combines a broadband label-free approach for ch
 emometric analysis of biological specimens with artificial intelligence to
 ols\, enabling users to unleash the full power of hyperspectral data. Such
  a system finds broad application in biomedical sectors where traditional 
 exogenous labeling is a limiting factor\, such as in live cell imaging\, m
 etabolomics\, and histopathology.&lt;/span&gt;&lt;/p&gt;\n&lt;p class=&quot;MsoNormal&quot;&gt;&lt;span l
 ang=&quot;EN-US&quot;&gt;&amp;nbsp\;&lt;/span&gt;&lt;/p&gt;\n&lt;p class=&quot;MsoNormal&quot;&gt;&lt;span lang=&quot;EN-GB&quot; st
 yle=&quot;mso-ansi-language: EN-GB\;&quot;&gt;[1] Zhang\, C. &amp;amp\; Cheng\, J.-X. Persp
 ective: Coherent Raman scattering microscopy\, the future is bright. APL P
 hotonics vol. 3 090901 (2018).&lt;/span&gt;&lt;/p&gt;\n&lt;p class=&quot;MsoNormal&quot;&gt;&lt;span lang
 =&quot;EN-GB&quot; style=&quot;mso-ansi-language: EN-GB\;&quot;&gt;[2] Fu\, D. et al. Quantitativ
 e Chemical Imaging with Multiplex Stimulated Raman Scattering Microscopy. 
 Journal of the American Chemical Society vol. 134 3623&amp;ndash\;3626 (2012).
 &lt;/span&gt;&lt;/p&gt;\n&lt;p class=&quot;MsoNormal&quot;&gt;&lt;span lang=&quot;EN-GB&quot; style=&quot;mso-ansi-langu
 age: EN-GB\;&quot;&gt;[3] De la Cadena\, A. et al. Broadband stimulated Raman imag
 ing based on multi-channel lock-in detection for spectral histopathology. 
 APL Photonics vol. 7 076104 (2022).&lt;/span&gt;&lt;/p&gt;\n&lt;p class=&quot;MsoNormal&quot;&gt;&lt;span
  lang=&quot;EN-US&quot;&gt;&amp;nbsp\;&lt;/span&gt;&lt;/p&gt;
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