BEGIN:VCALENDAR VERSION:2.0 PRODID:IEEE vTools.Events//EN CALSCALE:GREGORIAN BEGIN:VTIMEZONE TZID:America/Los_Angeles BEGIN:DAYLIGHT DTSTART:20260308T030000 TZOFFSETFROM:-0800 TZOFFSETTO:-0700 RRULE:FREQ=YEARLY;BYDAY=2SU;BYMONTH=3 TZNAME:PDT END:DAYLIGHT BEGIN:STANDARD DTSTART:20261101T010000 TZOFFSETFROM:-0700 TZOFFSETTO:-0800 RRULE:FREQ=YEARLY;BYDAY=1SU;BYMONTH=11 TZNAME:PST END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTAMP:20260228T175447Z UID:DBF137D9-51A5-416D-9400-DFDE0C759B65 DTSTART;TZID=America/Los_Angeles:20260319T113000 DTEND;TZID=America/Los_Angeles:20260319T131000 DESCRIPTION:Silicon Metasurfaces for DNA Synthesis\n\nAbstract:\n\nReady ac cess to long\, accurate\, and diverse synthetic DNA is essential for the r apid growth of synthetic biology — a field that genetically programs liv ing cells with new functions. Modern microarray-based DNA synthesizers can generate diverse pools of oligonucleotide (single stranded DNA) sequences in parallel. However\, each sequence is produced in limited quantity\, an d their yields decline with increasing oligo length due to cumulative synt hesis errors. These limitations complicate downstream sequence segregation and gene assembly. Attempts to address these challenges by enlarging and spacing synthesis sites farther apart reduce the total number of sequences that can be generated simultaneously\, thereby compromising synthesis div ersity.\n\n[]\n\nIn this talk\, I will introduce B-MOS (Metasurface Oligon ucleotide Synthesizer for Engineered Biology) — a novel platform that in tegrates silicon nanophotonics with solid-phase DNA synthesis to overcome these challenges.\n\nB-MOS employs dielectric metasurfaces composed of arr ays of high-index and low loss silicon nanoantennas (metasurfaces) pattern ed on glass as optically programmable synthesis sites. The unique optical signature of each metasurface — its spectral and polarization response — is lithographically encoded into the geometry and orientation of the s ilicon nanoantennas. Under global illumination\, only the metasurface tune d to the wavelength and polarization of the laser absorbs the optical ener gy and transduces it into highly localized heat to site-selectively activa te the synthesis reactions. Tuning the laser enables switching between the synthesis sites without moving parts or complex optical projection system s that lead to alignment errors.\n\nAs these nanostructures support sharp (high-Q) optical resonances\, crosstalk between the synthesis sites is min imized. These sharp resonances allow the dense spectral packing of indepen dently addressable synthesis within the tunable range of the laser\, there by maximizing synthesis diversity.\n\nUsing temperature as a programmable biochemical control knob\, I will demonstrate site-selective enzymatic inc orporation of fluorescent nucleotides onto surface-bound DNA using the enz yme terminal deoxynucleotidyl transferase. I will further discuss how inte grating B-MOS with microfluidics can enable post-synthesis site-selective amplification and spatial segregation of oligo strands for reliable gene a ssembly.\n\nFinally\, I will outline how B-MOS can be extended to RNA and peptide synthesis as well as other enzyme-driven processes. By resonant na nophotonics with programmable biochemical control\, B-MOS establishes a sc alable physical foundation for high-precision biomolecular manufacturing a nd next-generation molecular technologies.\n\nSpeaker:\n\nDr. Punnag Padhy \n\nPostdoctoral Scholar\n\nDepartment of Materials Science and Engineerin g\n\nStanford University\n\nAGENDA:\n\nThursday March 19\, 2026\n\n11:30 A M: Networking\, Pizza & Drinks\n\nNoon -- 1 pm: Seminar\n\nPlease register on Eventbrite before 9:30 AM on Thursday March 19\, 2026\n\n$4 IEEE membe rs $6 non IEEE members\n\n(discounts for unemployed and students )\n\nBldg : ==> Use corner entrance: Kifer Road / San Lucar Court ==> Do not enter a t main entrance on Kifer Road\, EAG Labs\, 810 Kifer Road\, Sunnyvale\, Ca lifornia\, California\, United States\, 95051 LOCATION:Bldg: ==> Use corner entrance: Kifer Road / San Lucar Court ==> Do not enter at main entrance on Kifer Road\, EAG Labs\, 810 Kifer Road\, Su nnyvale\, California\, California\, United States\, 95051 ORGANIZER:G.M.Friedman@ieee.org SEQUENCE:12 SUMMARY:Silicon Metasurfaces for DNA Synthesis URL;VALUE=URI:https://events.vtools.ieee.org/m/543428 X-ALT-DESC:Description: <br /><div class="eds-l-mar-vert-6 eds-l-sm-mar-ver t-4 eds-text-bm structured-content-rich-text">\n<div class="eds-text--left ">\n<h1 class="event-title css-0">Silicon Metasurfaces for DNA Synthesis</ h1>\n</div>\n</div>\n<div class="eds-l-mar-vert-6 eds-l-sm-mar-vert-4 eds- text-bm structured-content-rich-text">\n<div class="eds-text--left">\n<p>& nbsp\;</p>\n<p><strong>Abstract:</strong></p>\n<h3><em><strong>Ready acces s to long\, accurate\, and diverse synthetic DNA is essential for the rapi d growth of synthetic biology &mdash\; a field that genetically programs l iving cells with new functions. Modern microarray-based DNA synthesizers c an generate diverse pools of oligonucleotide (single stranded DNA) sequenc es in parallel. However\, each sequence is produced in limited quantity\, and their yields decline with increasing oligo length due to cumulative sy nthesis errors. These limitations complicate downstream sequence segregati on and gene assembly. Attempts to address these challenges by enlarging an d spacing synthesis sites farther apart reduce the total number of sequenc es that can be generated simultaneously\, thereby compromising synthesis d iversity.</strong></em></h3>\n<p>&nbsp\;<img src="https://events.vtools.ie ee.org/vtools_ui/media/display/424e45f3-2436-469a-831b-ce56033e2d34" alt=" " width="760" height="380"></p>\n<div id="creator-nav-root">\n<div class=" creator-workspace-layout events-workspace creator-workspace-layout-without -header" data-testid="creator-workspace-layout">\n<div class="creator-work space--no-tabs" data-testid="creator-workspace-main">\n<div class="eds-str ucture eds-structure--min-height eds-structure--independent-scrolling">\n< div class="eds-structure__body">\n<div class="eds-structure__main-mask" da ta-spec="eds-structure-main-mask">\n<div class="event-level-container">\n< div id="root">\n<div class="eds-structure eds-structure--min-height eds-st ructure--independent-scrolling" data-spec="eds-structure">\n<div class="ed s-structure__body eds-structure__body--overflow-set">\n<div class="eds-str ucture__main-mask eds-structure__main-mask--overflow-set" data-spec="eds-s tructure-main-mask">\n<div class="eds-structure__fixed-bottom-bar-layout-w rapper eds-structure__fixed-bottom-bar-layout-wrapper--absolute">\n<div cl ass="eds-fixed-bottom-bar-layout eds-fixed-bottom-bar-layout--absolute" da ta-spec="fixed-bottom-bar-layout">\n<div class="eds-fixed-bottom-bar-layou t__content">\n<div class="eds-structure__main-container"><main class="eds- structure__main" data-spec="eds-structure-main">\n<section class="eds-layo ut eds-layout--has-horizontal-gutters" data-spec="eds-layout">\n<div class ="eds-layout__body" data-spec="eds-layout__body">\n<div class="Form-module __wrapper___1sKak "><form class="css-10oami3 e1ft4gvv1" name="DetailsForm " novalidate="" data-testid="EventCreateDetailsForm">\n<div class="css-188 aeyp e9y8vn50">\n<div id="AboutThisEventSection" class="css-1g9pewn em1van 10" tabindex="0" role="button" data-testid="AboutThisEventSection" aria-la bel="Overview. Use this section to provide more details about your event. You can include things to know\, venue information\, accessibility options &mdash\;anything that will help people know what to expect.">\n<div class= "Section-module__SectionContainer___fNm4Y">\n<div id="AboutThisEventPrevie w" class="css-1dykrq ezg9ojv4" data-testid="AboutThisEventPreview">\n<div data-testid="ModulesListPreview">\n<div class="css-1hbyxwu e1pmrtpl0">\n<h 3><em><strong>In this talk\, I will introduce </strong></em><em><strong>B- MOS (Metasurface Oligonucleotide Synthesizer for Engineered Biology)</stro ng></em><em><strong>&nbsp\;&mdash\; a novel platform that integrates silic on nanophotonics with solid-phase DNA synthesis to overcome these challeng es.</strong></em></h3>\n<h3>&nbsp\;</h3>\n<h3><em><strong>B-MOS employs di electric metasurfaces composed of arrays of high-index and low loss silico n nanoantennas (metasurfaces) patterned on glass as optically programmable synthesis sites. The unique optical signature of each metasurface &mdash\ ; its spectral and polarization response &mdash\; is lithographically enco ded into the geometry and orientation of the silicon nanoantennas. Under g lobal illumination\, only the metasurface tuned to the wavelength and pola rization of the laser absorbs the optical energy and transduces it into hi ghly localized heat to site-selectively activate the synthesis reactions. Tuning the laser enables switching between the synthesis sites without mov ing parts or complex optical projection systems that lead to alignment err ors.</strong></em></h3>\n<p>&nbsp\;</p>\n<h3><em><strong>As these nanostru ctures support sharp (high-Q) optical resonances\, crosstalk between the s ynthesis sites is minimized. These sharp resonances allow the dense spectr al packing of independently addressable synthesis within the tunable range of the laser\, thereby maximizing synthesis diversity.</strong></em></h3> \n<p>&nbsp\;</p>\n<h3><em><strong>Using temperature as a programmable bioc hemical control knob\, I will demonstrate site-selective enzymatic incorpo ration of fluorescent nucleotides onto surface-bound DNA using the enzyme terminal deoxynucleotidyl transferase. I will further discuss how integrat ing B-MOS with microfluidics can enable post-synthesis site-selective ampl ification and spatial segregation of oligo strands for reliable gene assem bly.</strong></em></h3>\n<p>&nbsp\;</p>\n<h3><em><strong>Finally\, I will outline how B-MOS can be extended to RNA and peptide synthesis as well as other enzyme-driven processes. By resonant nanophotonics with programmable biochemical control\, B-MOS establishes a scalable physical foundation fo r high-precision biomolecular manufacturing and next-generation molecular technologies.</strong></em></h3>\n<p>&nbsp\;</p>\n</div>\n<div class="css- 1hbyxwu e1pmrtpl0">\n<h3><strong>Speaker:</strong></h3>\n<h3><strong>Dr. P unnag Padhy</strong></h3>\n<h3><strong>Postdoctoral Scholar</strong></h3>\ n<h3><strong>Department of Materials Science and Engineering</strong></h3> \n<h3><strong>Stanford University</strong></h3>\n</div>\n</div>\n</div>\n< /div>\n</div>\n</div>\n</form></div>\n</div>\n</section>\n</main></div>\n< /div>\n</div>\n</div>\n</div>\n</div>\n</div>\n</div>\n</div>\n</div>\n</d iv>\n</div>\n</div>\n</div>\n</div>\n<h3>&nbsp\;</h3>\n<h3><strong>AGENDA: </strong></h3>\n</div>\n</div>\n<div class="eds-l-mar-vert-6 eds-l-sm-mar- vert-4 eds-text-bm structured-content-rich-text">\n<div class="eds-text--l eft">\n<div class="css-188aeyp e9y8vn50">\n<div id="AboutThisEventSection" class="css-cd870x em1van10" tabindex="0" role="button" data-testid="About ThisEventSection" aria-label="Overview. Use this section to provide more d etails about your event. You can include things to know\, venue informatio n\, accessibility options&mdash\;anything that will help people know what to expect.">\n<div id="AboutThisEventPreview" class="css-1dykrq ezg9ojv5" data-testid="AboutThisEventPreview">\n<div data-testid="ModulesListPreview ">\n<div class="css-1hbyxwu e1pmrtpl0">\n<p><strong>Thursday March 19</str ong><strong>\, 2026</strong></p>\n<p><strong>11:30 AM: Networking\, Pizza &amp\; Drinks</strong></p>\n<p><strong>Noon -- 1 pm: Seminar</strong></p>\ n<p><strong>Please register on Eventbrite before 9:30 AM on</strong><stron g> Thursday March 19\, 2026</strong></p>\n<p><strong>$4 IEEE members&nbsp\ ; $6 non IEEE members </strong></p>\n<p><strong>(discounts for unemployed and students</strong> )</p>\n</div>\n</div>\n</div>\n</div>\n</div>\n</div >\n</div> END:VEVENT END:VCALENDAR