[Legacy Report] IEEE Swiss CAS/ED Sponsored Talk
Talk by CAS DLP Sandro Carrara
Abstract: The development of Integrated electrochemical CMOS-Bio-Sensors [1] for diagnosis and/or treatment of patients with specific physiological conditions (e.g., heart, cardiovascular, cancer diseases) or convalescents is a key factor to provide better, more rationale, effective and ultimately low-cost health care also at home. The ultimate goal of improved health care on those subjects is the extension of the patients’ autonomy, the possibility for auto-monitoring, the improvement of their comfort levels and their integration into everyday life. On-line monitoring is also required in professionals and recreational sportsmen training, as well as in elderly and/or disabled citizen care and/or people involved in public utilities (e.g. the public-transportation drivers). For those, it is a key aspect the maintenance of their safety by through embedded systems to alert emergency services in the event of a potentially dangerous situation. Some systems for on-line monitoring are available in the market. They use wearable devices (accelerometers, heartbeat monitoring system, etc). However, all these systems do not measure the human metabolism at molecular level (metabolites). The only available real-time, implantable/wearable systems for metabolic control are limited to glucose monitoring and used only for diabetic patients. However, electrochemical sensors may address so many other molecules, which have crucial relevance in human metabolism of chronic patients. So far, there are no available integrated nano-bio-systems for multi-metabolites, real-time, remote monitoring of the human metabolism. Thus, the aim of this plenary speech is to present the most recent results obtained within the frame of the project i-ironIC (a project funded by the Swiss National Program NanoTera.ch) and provide new and innovative concepts for multi-panel, highly integrated, fully implantable, remotely powered and real-time monitoring systems for human metabolism at molecular level. The core of the developed system is an extremely integrated implantable chip that can be seen as a tiny molecular laboratory located under the patient’s skin for providing molecular telemetry. The considered metabolic molecules are glucose, lactate, glutamate, ATP [2], and anticancer drugs as well as anti-inflammatory ones [3]. In case of drugs, the specificity of electrochemical sensors is improved at system level [4]. The proposed nanotechnology is based on carbon nanotubes to improve the sensors performance [3, 5]. To pursue the molecular detection, innovative VLSI solutions [6] are discussed including new ideas on the remote powering [7]. The new approach is obtained by integrating nano/bio/micro/CMOS/SW/RF systems in three devices: (i) a fully implantable sensors array for data acquisition (the tiny laboratory!); (ii) an on-skin intelligent-patch for remote powering and Bluetooth® connections; (iii) a mobile phone for data collection, elaboration, storage, and retransmission.
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- Date: 17 Oct 2014
- Time: 04:00 PM to 05:00 PM
- All times are (UTC+01:00) Bern
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EPFL
New Frontiers in Human Telemetry
Biography:
Address:Lausanne, Switzerland, Switzerland