Histotripsy: Non-Invasive Ultrasonic Surgery. The Journey From Science Lab to the Clinic
Histotripsy is a method of non-invasive ultrasonic surgery using very intense pulses of focused ultrasound to mechanically fracture tissue. As of July 2025, histotripsy systems have been installed at more than 50 medical centers worldwide for ablation of liver tumors. This talk summarizes the approximately 25 year process of translating the physical mechanism of ultrasonically generated cavitation to a clinical product. I will also highlight a number of the substantial challenges faced by academics attempting to pursue scientific research translation, a large number of mistakes, and a few lucky breaks that lead to our success.
This presentation is a virtual event hosted by the Engineering Medicine and Biology Chapter of SE Michigan IEEE Section
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Timothy Hall
Biography:
Timothy L Hall is a Research Scientist with the Department of Biomedical Engineering at the University of Michigan. He specializes in the design and fabrication of instrumentation for medical ultrasound and promoting translational research in applications for histotripsy. He is a co-founder and consultant for Histosonics Inc, maker of robotic systems for image guided histotripsy cancer ablation.