Speaker: Asst. Prof. Rohat Melik, TOBB-ETÜ

Topic: "Modulation of Ion Concentration In-Vivo"

Location: Middle East Technical University, Ankara, Turkey

Abstract: Our motion and behavior are as a result of the change of the cellular membrane potential. Therefore, by controlling the membrane potential in-vivo, we can control our motion and behavior. In our work, we applied extrinsic current and changed the ion concentration gradient in-vivo hence; changed the membrane potential in-vivo. Therefore, we proposed and developed two fundamental technologies: changing ion concentration gradient in-vivo and changing membrane potential in-vivo. We used these fundamental technologies for therapeutics of neurological disorders. Approximately 6 million people are paralysis in US (1.9%). Conventional Functional Electrical Stimulation (FES) aims to restore neurological functions such as standing, ambulation etc. However, there is no widely acceptable FES system because of high-energy expenditure and stimulation of nearby sensory nerves, causing pain. By using our novel electrochemical stimulation and blocking method, we modulated ion concentration around the sciatic nerve of a frog in-vivo using ion-selective membrane (ISM), hence; lowered the stimulation current therefore decreased the energy expenditure. We also lowered the blocking current as a result localized stimulation and reduced pain.

Bio: Dr. Melik is currently an Assistant Professor in the Department of Electrical and Electronics (EE) Engineering at TOBB University of Economics & Technology, Ankara, Turkey. He received B.S. degree in Electrical and Electronics Engineering (major) and in International Economics (minor) from Middle East Technical University (METU), Turkey in 2004. In his Ph.D. study, Dr. Melik has worked on smart orthopaedic implants for early-diagnostics of orthopaedic traumas. In 2010, he received his Ph.D. in Electrical and Electronics Engineering from Bilkent University, Turkey. He worked as a postdoctoral fellow in the Department of Electrical Engineering and Computer Science at Massachusetts Institute of Technology (MIT) in 2011-2012. Since 2013, he continues his career as an academic at TOBB University of Economics & Technology. His research interest is particularly in implantable electronics, which has clinical applications in real life especially for the therapeutics of neurological disorders. He is the recipient of Leopold B. Felsen Award for Excellence in Electromagnetics.

  Date and Time




  • Ankara, Ankara
  • Turkey


Asst. Prof. Rohat Melik of TOBB


Modulation of Ion Concentration In-Vivo



Address:Ankara, Turkey