[Legacy Report] Microfluidic devices with integrated structured electrodes for on-chip sensing


The development of widely applicable point-of-care sensing and diagnostic devices can benefit from simple and inexpensive fabrication techniques that expedite the design, testing, and implementation of lab-on-a-chip devices. In particular, electrodes integrated within microfluidic devices enable the use of electrochemical techniques for the label-free detection of relevant analytes. This work presents a novel, simple, and cost-effective bench-top approach for the integration of high surface area three-dimensional structured electrodes fabricated on polystyrene (PS) within poly(dimethylsiloxane) (PDMS)-based microfluidics. The fabrication and bonding processes are shown to have no effect on sensing electrode performance. Two configurations of three-electrode electrochemical cell are tested, and a salt bridge-free configuration is used for sensing. Finally, the on-chip sensing capabilities of the electrochemical cell are demonstrated with a model redox compound, where the high surface area structured electrodes exhibit ultra-high sensitivity. We propose that the developed approach can significantly expedite and reduce the cost of fabrication of sensing devices where arrays of functionalized electrodes can be used for point-of-care analysis and diagnostics.

  Date and Time




  • Quebec City, Quebec
  • Canada


McMaster University, Hamilton, Ontario, Canada


Microfluidic devices with integrated structured electrodes for on-chip sensing


Address:Quebec, Canada