[Legacy Report] LIGHT and LIFE: Applications to Biology and Medicine

#Laser #spectroscopy #vibrational #cell-drug #interaction #lab-on-a-chip

Lasers have become an essential light source in spectroscopic applications due to their inherent coherence and intensity. These properties enable both time (fs) and spacial (nm) resolutions required to study materials at the nanoscopic to microscopic level and also their dynamics in femtosecond to seconds time scale. In this talk we will present various applications of laser spectroscopy, particularly vibrational spectroscopy, in biology and medicine. In the case of biology and medicine, we would present results of both infrared and Raman microscopic approaches to studying tissues, cell-drug interactions, bacterial classifications, sepsis, muscle disorders and lab-on-chip applications. We demonstrate subjective classification of grade IV glioblastoma brain cancer tissues using infrared microscopy. Our study on effect of drugs on various cancer cell lines resulted in identification of propionylation which may be an indication of cancer cell death. During the lecture we would also present results of new technological applications in classification of bacterial species which are relevant to human diseases. We have also explored sepsis and muscle disorders using model systems, such as, mice and drosophila, respectively. Further, very recently we have built a lab-on-chip system for use with Raman microscopy. We demonstrate the utility in combining surface enhanced Raman with lab-on-chip to study extremely low concentration of biofluids. References: (i) Raman and mid-infrared spectroscopic imaging: applications and advancements, S Umapathy, et.al., Current Science, 2014; (ii) Molecular profiling of sepsis in mice using Fourier Transform Infrared Microspectroscopy, S Umapathy, et. al., J. Biophotonics, 2015; (iii) Raman Spectroscopic Studies on Screening of Myopathies, S Umapathy et.al., Anal. Chem., 2015; (iv) Infrared Spectroscopic Studies to Understand the Effect of Drugs at Molecular Level , S Umapathy, SPIE Proceedings, 2013.

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• Newark, New Jersey
• United States

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• Co-sponsored by NJIT, AP03/MTT17, PHO36