Distinguished Lecture by Prof. Murat Arcak
Brief Biography (from http://www.ieeecss.org/contacts/murat-arcak):
Murat Arcak received the B.S. degree from the Bogazici University, Istanbul, Turkey (1996) and the M.S. and Ph.D. degrees from the University of California, Santa Barbara (1997 and 2000). His research is in dynamical systems and control theory with applications to synthetic biology, multi-agent systems, and transportation. Prior to joining Berkeley in 2008, he was a faculty member at the Rensselaer Polytechnic Institute. He received a CAREER Award from the National Science Foundation in 2003, the Donald P. Eckman Award from the American Automatic Control Council in 2006, the Control and Systems Theory Prize from the Society for Industrial and Applied Mathematics (SIAM) in 2007, and the Antonio Ruberti Young Researcher Prize from the IEEE Control Systems Society in 2014. He is a member of SIAM and a fellow of IEEE.
Title: SPATIAL PATTERNS OF GENE EXPRESSION IN MULTICELLULAR ENSEMBLES
Abstract: Breaking symmetry in spatially distributed systems is a fascinating dynamical systems problem and is of fundamental interest to developmental biology. In the first part of this talk we discuss feedback mechanisms that enable formation of gene expression patterns in multi-cellular organisms by destabilizing a spatially homogeneous steady state. With the help of dynamical models we reveal the key structural properties that are necessary for patterning and present novel synthetic gene networks built upon these models. In the second part we relax the instability condition and show that patterns can emerge from the amplification in certain spatial modes of spatially varying inputs, such as morphogen gradients. This is analogous to the way a two-dimensional filter modifies the frequency components of an image. We apply the framework to two systems in developmental biology: the Notch-Delta interaction that shapes Drosophila wing veins and the Sox9/Bmp/Wnt network responsible for digit formation in vertebrate limbs.
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- IIT Delhi
- Hauz Khas
- New Delhi, Delhi
- India 110016
- Building: MS 105
- Room Number: MS 105 (next to Cafe Coffee Day)
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- Co-sponsored by IIT Delhi
Speakers
Prof. Murat Arcak of UC Berkeley
SPATIAL PATTERNS OF GENE EXPRESSION IN MULTICELLULAR ENSEMBLES
Breaking symmetry in spatially distributed systems is a fascinating dynamical systems problem and is of fundamental interest to developmental biology. In the first part of this talk we discuss feedback mechanisms that enable formation of gene expression patterns in multi-cellular organisms by destabilizing a spatially homogeneous steady state. With the help of dynamical models we reveal the key structural properties that are necessary for patterning and present novel synthetic gene networks built upon these models. In the second part we relax the instability condition and show that patterns can emerge from the amplification in certain spatial modes of spatially varying inputs, such as morphogen gradients. This is analogous to the way a two-dimensional filter modifies the frequency components of an image. We apply the framework to two systems in developmental biology: the Notch-Delta interaction that shapes Drosophila wing veins and the Sox9/Bmp/Wnt network responsible for digit formation in vertebrate limbs.
Biography:
Murat Arcak received the B.S. degree from the Bogazici University, Istanbul, Turkey (1996) and the M.S. and Ph.D. degrees from the University of California, Santa Barbara (1997 and 2000). His research is in dynamical systems and control theory with applications to synthetic biology, multi-agent systems, and transportation. Prior to joining Berkeley in 2008, he was a faculty member at the Rensselaer Polytechnic Institute. He received a CAREER Award from the National Science Foundation in 2003, the Donald P. Eckman Award from the American Automatic Control Council in 2006, the Control and Systems Theory Prize from the Society for Industrial and Applied Mathematics (SIAM) in 2007, and the Antonio Ruberti Young Researcher Prize from the IEEE Control Systems Society in 2014. He is a member of SIAM and a fellow of IEEE.
(From http://www.ieeecss.org/contacts/murat-arcak)