IEEE AP/MTT/EMC/ED TURKEY CHAPTER SEMINAR SERIES -- SEMINAR 62

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13 December 2019 (12:40):  IEEE AP/MTT/EMC/ED Turkey Seminar Series (S.62)

Speaker: Asst. Prof. Arif Engin Çetin, İzmir Biomedicine and Genome Center

Topic: "The Use of Optics and Nano-Plasmonics for Point-of-Care Analysis in Resource-Poor Settings"

Location: Middle East Technical University, Ankara, Turkey

Abstract: In this talk, I will introduce portable and low-cost plasmonic biosensor platforms for resource-poor settings.

In recent years, research on plasmonic systems to overcome the limitations of biosensors brought new functionalities that do not exist in the traditional optical approaches. New generation plasmonic biosensor systems enable real-time detection of biomolecules at very low analyte concentrations without the need for optical labels. These systems stimulate optical responses with very sensitivity and high quality factor by employing surface plasmons, which are powerful surface electromagnetic waves, strongly localized in nanometer scale. Employing surface plasmons, conventional detectors, e.g., spectrometers, can be used to distinguish signal variations generated by the targeted biomolecules of interest.

In conventional spectrometer-based biosensing systems based on refractive index sensing, the presence of biomolecules in the samples are determined by monitoring the spectral shifts within the plasmonic responses. These platforms enable the detection of analytes, e.g., viruses or bacteria, at medically relevant concentrations that need to be identified for disease diagnostics in clinics, with simpler sample preparation protocols. Multiplexing and high-throughput capability of biosensors can be improved by integrating large-scale and high-density plasmonic chips to imaging-based platforms. By integrating plasmonic nano-chips into a telemedicine platform, these new generation plasmonic biosensors can be transformed into a portable platform to be deployed in resource-poor settings. These platforms can be also integrated to portable read-out devices, e.g., laptops or mobile phones, to provide highly sensitive label-free biosensing in inadequate medical infrastructure.

By integrating microfluidic technologies with portable plasmonic biosensing platforms, real-time analysis of protein-protein interaction kinetics can be also demonstrated in a cost-effective manner. Using powerful data processing algorithms, our microfluidic technology can monitor biomolecular binding interactions at pico-molar concentration levels.

Bio: Arif E. Cetin is a Research Group Leader in Izmir Biomedicine and Genome Center (IBG), Izmir, Turkey. Dr. Cetin received his BS degree in Electrical and Electronics Engineering and MS degree in Electrical and Computer Engineering both from Koc University, Istanbul, Turkey. He received his PhD degree in Electrical Engineering from Boston University, Boston, MA, USA. He worked as a postdoctoral fellow at EPFL, Lausanne, Switzerland in 2013–2014 and at MIT, Cambridge, MA, USA in 2014–2016, and as a research scientist at Omniome, Inc. San Diego, CA, USA in 2016–2018.

Dr. Cetin is pursuing research on optical nano-biosensors integrated with microfluidic platforms. He is developing hand-held biosensors for high-throughput and multiplexed biosensing. Recently, he is also developing a unique label-free technique for high-throughput DNA sequencing.



  Date and Time

  Location

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  • Ankara, Ankara
  • Turkey

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  Speakers

Asst. Prof. Arif Engin Cetin

Topic:

The Use of Optics and Nano-Plasmonics for Point-of-Care Analysis in Resource-Poor Settings