Disposable Photonics for Biosensing

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Decades of research have shown that biosensors using photonic circuits fabricated using CMOS processes can be highly sensitive, selective, and quantitative. Unfortunately, the cost of these sensors combined with the complexity of sample handling systems has limited the use of such sensors in clinical diagnostics. This has become particularly apparent in recent months, as concepts of viral and antibody testing have become common conversation in the context of the COVID-19 pandemic. Leveraging our partnerships with the American Institute for Manufacturing Integrated Photonics (AIM Photonics), headquartered in upstate New York, as well as NY CREATES, we have developed a new “disposable photonics” sensor platform in which rice-sized (1 × 4 mm) silicon nitride ring resonator sensor chips are paired with plastic micropillar fluidic cards for sample handling and optical detection. We demonstrate the utility of the platform in the context of detecting human antibodies to SARS-CoV-2, both in convalescent COVID-19 patients and for subjects undergoing vaccination. Given its ability to provide quantitative data on human samples in a simple, low-cost single-use format, we anticipate that this platform will find broad utility in clinical diagnostics for a broad range of assays.



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  • Date: 06 Oct 2021
  • Time: 12:00 PM to 01:00 PM
  • All times are America/New_York
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Virtual Webinar - Zoom Link will be forwarded to registrants prior to event.

  • Starts 16 July 2021 09:24 AM
  • Ends 06 October 2021 12:00 PM
  • All times are America/New_York
  • No Admission Charge


  Speakers

Ben Miller

Biography:

Prof. Benjamin L. Miller completed his undergraduate studies at Miami University (Ohio), receiving degrees in Chemistry (B.S.), Mathematics (A.B.), and German (A.B.) in 1988. He next moved to Stanford University, where he carried out his Ph. D. research in Chemistry under the direction of Paul Wender. Following a stint as an NIH postdoctoral fellow at Harvard in Stuart Schreiber’s laboratory, he joined the University of Rochester faculty in 1996, where he is currently Dean’s Professor of Dermatology, Biochemistry and Biophysics, Biomedical Engineering, Materials Science, and Optics. His group’s expertise in molecular recognition, combinatorial chemistry, nanotechnology, and optical sensing has been applied to the development of novel optical biosensor platforms, and synthetic compounds targeting RNAs involved in several human diseases. He is a Fellow of the OSA, AIMBE, and AAAS. Miller is a founder of Adarza BioSystems, Inc., a multiplex optical biodetection company located in St. Louis, MO. He is also the Academic Lead for Integrated Photonic Sensors in AIM Photonics.