Nanocarbons for Biology and Medicine: Sensing, Imaging, and Drug Delivery
Nanocarbons with different dimensions (e.g., 0D fullerenes and carbon nanodots, 1D carbon nanotubes and graphene nanoribbons, 2D graphene and graphene oxides, and 3D nanodiamonds) have attracted enormous interest in numerous applications due to their unique properties. Among them, theranostics (i.e. therapeutics and diagnostics) is one of the most intensely studied applications, as these nanocarbon materials serve as excellent biosensors, versatile drug/gene carriers for specific in vivo targets, effective photothermal nanoagents for cancer therapy, and promising fluorescent nanolabels for cell and tissue imaging. We first introduce the different carbon allotropes usable for theranostic applications, their physical and chemical properties, and their respective preparation and surface functionalization approaches. The protocols for both in vitro and in vivo theranostic applications are then described, followed by toxicity and biodegradability implications. The design considerations will outline the key unifying set of foundational first principles for investigating and realizing effective, biocompatible, and nontoxic nanocarbon materials-based models for cancer theranostics applications. Finally, the challenges and novel theranostic protocols for hard-to-treat cancers and other diseases will be summarized. This talk will present a guideline on the selection strategy of nanocarbon materials accordingly.
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- Physics Auditorium, Research School of Physics
- The Australian National Unveristy
- Canberra, Australian Capital Territory
- Australia 2601
- Building: B160
- Room Number: R3.56
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Dr. Zhe Li
Research School of Phyiscs
The Australian Natioanl University, Canberra, ACT 2601
Speakers
Ken-Tye Yong
Nanocarbons for Biology and Medicine: Sensing, Imaging, and Drug Delivery
Biography:
Prof. Ken-Tye Yong is a Professor in the School of Biomedical Engineering and the Associate Dean (external engagement) in the Faculty of Engineering at University of Sydney. Yong’s research group interests include engineering nanomaterials for biophotonic and nanomedicine applications, nanotoxicity and pharmacokinetics of nanomaterials, fabricating miniaturized microdevices for biological applications, designing nanosensors for biodetection, modelling of microfluidics and plasmonic sensor systems, creating devices for nanophotonics studies, applying triboelectric nanogenerator for drug delivery applications, the developing of RNA delivery platform based on conjugated oligoelectrolytes and applications of wearable technologies.
Yong is the Fellow of Optical Society of America, Fellow of Royal Society of New South Wales, Fellow of Engineers Australia, Fellow of Royal Society of Chemistry, Fellow of Royal Society of Biology, Fellow of Institute of Physics, Fellow of Materials, Minerals and Mining, and Senior Member of IEEE.
Yong’s team has received major grants to support technology transfer of his research work into commercial applications and he is actively working with industries and government agencies to explore new avenues for several of his inventions. His team has developed ultrasensitive portable microfiber sensor device to detect and monitor the contaminants in drinking water and this invention has won the Gold Medal in the 70th International Trade Fair Ideas - Inventions New Products (iENA), the 46th International Exhibition of Inventions Geneva and recognition from MIT Technology Review. Yong is the co-founder of two start-ups and is a passionate advisor and mentor to entrepreneurial students.
Address:School of Biomedical Engineering , University of Sydney, Sydney, Australia, 2006