Living Metasurface Biosensors for Bioanalysis
SPEAKER
Chia-Hung Chen
Department of Biomedical Engineering, City University of Hong Kong
ABSTRACT
Multiplexed single-cell analysis is revolutionizing biomarker discovery for disease monitoring, thus advancing precision medicine. However, traditional immunosorbent assays often lack efficiency, while droplet microfluidics require custom assays for each biomarker, posing significant challenges. To overcome these limitations, we have developed a high-throughput cell membrane immunosorbent assay utilizing cholesterol-linked antibodies (CLAbs). This innovative method seamlessly integrates the specificity of immunosorbent assays with the scalability of microfluidics, allowing for concurrent analysis of cell surface proteins and secretions. With our technique, we can rapidly screen cells at a rate of approximately 1,000 per second, enabling the differentiation between healthy and diseased states, such as in nasopharyngeal carcinoma. By identifying unique immune cell clusters, our approach holds promise for guiding precision therapy in various diseases.
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- New Jersey Institute of Technology
- Newark, New Jersey
- United States
- Building: ECEC Building
- Room Number: Room 202
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- Co-sponsored by New Jersey Institute of Technology
- Starts 20 May 2024 04:00 AM UTC
- Ends 23 May 2024 04:00 AM UTC
- No Admission Charge
Speakers
Living Metasurface Biosensors for Bioanalysis
Chia-Hung Chen
Department of Biomedical Engineering, City University of Hong Kong
Biography:
Dr. Chia-Hung Chen is an Associate Professor in the Department of Biomedical Engineering at City University of Hong Kong, with extensive experience in developing microfluidic platforms for biological analysis. He obtained his Ph.D. from the University of Cambridge and completed postdoctoral studies at the Massachusetts Institute of Technology. Dr. Chen is a pioneer in microfluidic technologies for single-cell assays. He has authored over 80 peer-reviewed journal papers, including publications in Nature Communications, PNAS, JACS, Advanced Materials, Advanced Functional Materials, Analytical Chemistry and Lab on a Chip, and has delivered more than 60 plenary, keynote, and invited talks.
Notably, Dr. Chen has been awarded more than 20 international competitive external grants from Singapore, Hong Kong, and China as a Principal Investigator over the past six years. These grants include the General Research Fund (GRF), Health and Medical Research Fund (HMRF), Innovation and Technology Fund (ITF), and Research Impact Fund (RIF) in Hong Kong; the National Natural Science Foundation of China (NSFC) in China; and the National Medical Research Council (NMRC), Ministry of Education (MOE) Tier-2 grants, National Research Foundation (NRF) Competitive Research Program (CRP), and Singapore-MIT Alliance for Research and Technology (SMART) in Singapore. Furthermore, he has collaborated with data scientists and clinicians at the Genome Institute of Singapore, Singapore General Hospital, and Massachusetts General Hospital to develop integrative new point-of-care microfluidic devices for biomedical applications. Dr. Chen has been recognized as an Emerging Investigator by Lab on a Chip.
In this talk, Dr. Chen will introduce a new microfluidic living metasurface biosensor designed to screen multiplexed single-cell secretions. This innovation can be used to screen single immune cell secretions and analyze transcriptomic profiles, visualizing their interactions within the physiological environment in vivo for precision physiological profiling.