Microfluidic Dielectric Biosensors for Point-of-Care Assessment of Hemostasis: From Conceptualization to Clinical Translation
Point-of-care (POC) diagnostic devices hold great promise to significantly impact healthcare delivery and address health disparities. These devices enable a shift in focus away from the utilization of high-cost specialized care for the treatment of late-stage diseases toward predictive, preventative, participatory, and personalized healthcare for more effective disease monitoring and management.
In this seminar, I will present our work on ClotChip® – a microfluidic sensor that utilizes dielectric spectroscopy for POC assessment of blood coagulation disorders with <10 µL of whole blood. Specifically, I will analyze a simple circuit model that accurately captures the frequency-dependent dielectric behavior of human whole blood placed within a microfluidic channel. I will then discuss how temporal variation in the dielectric properties of a coagulating blood sample at 1 MHz provides information about cellular (i.e., platelet) and non-cellular (i.e., coagulation factor) abnormalities in clot formation, as well as about the fibrinolytic system that regulates clot resolution to prevent thrombotic occlusions.
Finally, to establish the utility of ClotChip® as a platform technology for POC assessment of hemostasis, I will share our results from pilot clinical studies with ClotChip® on monitoring anticoagulation therapy with direct oral anticoagulants (DOACs) – a new class of FDA-approved blood thinners – as well as coagulation factor replacement therapy in hemophilia care management. Results from correlative studies between ClotChip® and clinically relevant global hemostatic assays such as rotational thromboelastometry (ROTEM) are also provided.
Date and Time
Location
Hosts
Registration
- Date: 30 Oct 2024
- Time: 02:30 PM to 04:00 PM
- All times are (UTC+00:00) Edinburgh
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- Barlow Room (Room 807),
- Malet Place,
- London , England
- United Kingdom WC1E 7JE
- Building: Roberts Building
- Room Number: 807
- Starts 09 October 2024 12:00 AM
- Ends 30 October 2024 12:00 AM
- All times are (UTC+00:00) Edinburgh
- No Admission Charge
Speakers
Pedram of Case Western Reserve University, Cleveland, OH, USA.
Microfluidic Dielectric Biosensors for Point-of-Care Assessment of Hemostasis
Biography:
Pedram Mohseni is the Goodrich Professor of Engineering Innovation and Inaugural Chair of the Electrical, Computer, and Systems Engineering Department at Case Western Reserve University, Cleveland, OH, USA. He received the B.S. degree from the Sharif University of Technology, Tehran, Iran, in 1996, and the M.S. and Ph.D. degrees from the University of Michigan, Ann Arbor, MI, USA, in 1999 and 2005, respectively, all in electrical engineering. His main research interests are in analog/mixed-signal/RF integrated bioelectronics, wireless power/data transfer to biomedical implants, translational microfluidics, and microassays for point-of-care/point-of-injury diagnostics. His research activities have resulted in 2 book chapters, over 155 refereed publications, and 15 issued U.S. and international patents. He was the General co-Chair of the 2018 IEEE Biomedical Circuits and Systems (BioCAS) conference and will serve again as the General co-Chair of the conference in 2025. He currently serves as the Editor-in-Chief of the IEEE Transactions on Biomedical Circuits and Systems (TBioCAS). Dr. Mohseni was inducted into the U.S. National Academy of Inventors (NAI) in 2023 as a Senior Member for producing biomedical technologies that bring real impact on the welfare of society.
Address:United Kingdom