Novel Magnetic Resonance Imaging-Guided Ultrasound-Stimulated Microbubble Radiation Treatment for Patients with Chest-Wall and Locally Advanced Breast Cancer
The IEEE Magnetics Toronto Section invites you to a seminar exploring advancements in cancer treatment through the application of ultrasound-stimulated microbubbles (USMB) to enhance external beam radiotherapy. Previous studies have demonstrated that USMBs can amplify radiotherapy effects by up to 40-fold, offering significant promise for improving therapeutic outcomes.
This presentation will focus on an ongoing phase I clinical trial investigating USMBs as an adjunct to fractionated radiation therapy in patients with locally advanced breast cancer and inoperable tumors near the chest wall. Central to the trial is the Symphony MRI-guided FUS system, a pioneering technology developed by Arrayus Technologies. This system integrates:
- A large-aperture, densely populated phased array for fully electronic beam steering.
- Advanced MRI-guided spatial targeting with finely adjustable treatment contouring.
- Real-time magnetic resonance thermometry for precise monitoring and control.
Date and Time
Location
Hosts
Registration
- Date: 28 Nov 2024
- Time: 07:00 PM UTC to 08:00 PM UTC
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- Toronto Metropolitan University
- 350 Victoria Steet
- Toronto, Ontario
- Canada M5B2K3
- Building: Kerr Hall South
- Room Number: KHS369
- Click here for Map
- Starts 21 November 2024 05:00 AM UTC
- Ends 28 November 2024 05:00 AM UTC
- No Admission Charge
Speakers
David Alberico
Novel Magnetic Resonance Imaging-Guided Ultrasound-Stimulated Microbubble Radiation Treatment
Abstract - Previous studies have demonstrated the potential for ultrasound-stimulated microbubbles (USMB) to enhance the effects of external beam radiotherapy for cancer treatment by as much as 40-fold. The microbubbles are injected into the bloodstream before being stimulated by focused ultrasound (FUS) applied at the tumor location. We are presently conducting a phase I clinical trial using USMBs to assess the enhancement in fractionated radiation treatment for patients with locally advanced breast cancer and inoperable breast tumors close to the chest wall. The treatments are being performed with an MRI-guided FUS system developed by Arrayus Technologies. This system, called the Symphony, features a densely populated large-aperture phased array with fully electronic beam steering, MRI-guided spatial targeting with finely adjustable treatment contouring, and real-time MR thermometry. The primary aim of this research is to evaluate both tumor response to USMB-enhanced radiotherapy in humans and the safety profile of MRI-guided USMB treatment using the Symphony FUS system.
Biography:
David Alberico is a research technician at Sunnybrook Research Institute’s Physical Sciences Platform, where he works with Dr. Gregory Czarnota studying ultrasound-based techniques for cancer therapy. He completed his MEng in biomedical engineering at Toronto Metropolitan University. His research interests include quantitative ultrasound imaging, quantitative photoacoustic imaging, and high-intensity focused ultrasound.
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