An Electrical Perspective of the Heart Function and Disease


The contraction of the heart is highly coordinated for pumping blood through the body. Generation and conduction of electrical signals, known as action potentials, underlie the sequential contraction of the heart muscle. A very large number of complex interacting ionic channels in each heart cell are involved in generation of action potentials and propagation of membrane potentials. Mathematical modeling and computational simulations have proven to be indispensable tools for understanding these interactions, and investigating heart function and dysfunction. Importantly, mathematical/computational modeling are also greatly facilitating our understanding of drugs and their actions on the heart.

The aim of this project is to investigate the effect of structural heart disease, such as fibrosis, tissue necrosis, etc., which result in abnormalities of the electrical properties of the heart. Importantly, this project investigates the interaction of drugs with structural abnormalities and aims to predict life-threatening drug related interactions.

In this presentation, the speaker will present an overview of the heart from an electrical perspective. Examples of aberrant electrical/chemical events will be presented that can result in diseases and life-threatening events, such as cardiac arrhythmia. Emerging results from my ongoing research will be presented to show how we are using mathematical modeling, machine learning, and high-performance computing to accelerate discovery of novel cures and drugs.


  Date and Time




  • Date: 07 Dec 2017
  • Time: 06:30 PM to 08:00 PM
  • All times are (GMT-06:00) US/Central
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  • Bradley University
  • Peoria, Illinois
  • United States 61625
  • Building: Jobst Hall
  • Room Number: 330
  • Click here for Map

  • Dr. Anu A. Gokhale

  • Co-sponsored by Dr. In Soo Ahn, Professor and Chair, ECE Dept. Bradley University
  • Starts 21 November 2017 12:00 AM
  • Ends 07 December 2017 11:00 AM
  • All times are (GMT-06:00) US/Central
  • Admission fee ?


Mohammad S. Imtiaz, Ph.D.


Dr. Imtiaz has a multi-disciplinary training with a Bachelor in Electrical Engineering (USA) and a PhD from the faculty of Medicine (Australia, 2003). For over 15 years now, Dr. Imtiaz has applied mathematical modeling and computation to conduct multi-disciplinary research in clinical and life sciences. One of Dr. Imtiaz’s research area is computational cardiology. This area of research depends upon draws upon diverse fields, such as electrophysiology, pharmacology, biophysics, mathematics and computation.

Mohammad S. Imtiaz, Ph.D. of Bradley University


An Electrical Perspective of the Heart Function and Disease


Address:Peoria, IL, United States


6:30 - 7:30: Talk including Q&A (PDH certificates available for IEEE members)

7:30 - 7:55: Networking & Refreshments

7:55 - 8:00: Wrap-up and Closing