IEEE UFFC Seattle Tech Talk - Optimized ultrasound neuromodulation and wearables for behavioral control and clinical applications

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The Seattle Chapter of the IEEE Ultrasonics, Ferroelectrics, and Frequency Control Society (UFFC-S) aims to provide UFFC-S members with opportunities for professional and personal growth as well as network with the local, vibrant UFFC community.

Dr. Keith Murphy, PhD will be our guest speaker.  Dr. Murphy is Co-Founder and CTO of Attune Neurosciences which is developing next-generation lightweight wearable devices with bilateral, multi-element, electronically steered arrays. Prior to co-founding Attune Neurosciences, he received his training in neuroscience and behavioral genetics at the Scripps Research Institute and Florida Atlantic University followed by a post-doctoral fellowship at Stanford University to study the vagus nerve and its role in sleep regulation. 

Dr. Murphy will present on "Optimized ultrasound neuromodulation and wearables for behavioral control and clinical applications." 

This meeting will be virtual only. 



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  • Starts 16 September 2025 01:45 AM UTC
  • Ends 24 September 2025 12:00 AM UTC
  • No Admission Charge


  Speakers

Dr. Keith Murphy, PhD of Attune Neurosciences

Topic:

Optimized ultrasound neuromodulation and wearables for behavioral control and clinical applications

Focused ultrasound has all of the features of a perfect brain therapy; non-invasive, precise spatial and temporal control, and lightweight electronics. However, our shallow understanding of effective parameters has prohibited greater adoption. Here we explore new tools enabling rapid exploration of this high dimensional space. We first develop a deep brain optical recording method in freely behaving mice enabling bidirectional neuronal control, control of epileptiforms, and on-command walking behavior through hyper-sensitive hypothalamic sub-region targeting. Next we developed a self-registering, dynamically steered wearable for human therapeutic application. This user-centric design has enabled discovery of target specific therapeutic protocols for obsessive-compulsive disorder, depression, and chronic pain. Collectively, our work demonstrates the potential for FUS in next-generation brain therapeutics.

Biography:

 

Photo of Keith Murphy

 

Dr. Keith Murphy received his training in neuroscience and behavioral genetics at the Scripps Research Institute and Florida Atlantic University. There, he developed high-throughput tools for monitoring animal behavior during optogenetic and transgenic manipulations of discrete brain circuits. Keith then joined Stanford University as a postdoctoral fellow supported by the Ruth L. Kirschstein National Research Service Award, studying the vagus nerve and its role in sleep regulation. He developed the first system integrating deep-brain optical recordings of neuronal activity with ultrasound neuromodulation in freely behaving animals, enabling precise circuit control and monitoring of brain activity during natural behavior. Using this tool, he demonstrated cell type-specific effects, optimized protocols for arousal, sleep, and walking behaviors, and provided preclinical evidence of epileptiform suppression.

Keith currently serves as the Co-founder and CTO of Attune Neurosciences developing next-generation lightweight wearable devices with bilateral, multi-element, electronically steered arrays. He leads the scientific investigation of neuropathic and psychiatric conditions, cognitive enhancement, and innovations enabling powerful ultrasound therapies in a wearable form factor. Attune has received support from leading investment groups, the NIH, and the US military. 

Keith continues to contribute to the open ultrasound neuromodulation community through his leadership in the ITRUSST practical guide, the creation of open-source software, and his collaboration with Dr. Kim Butts Pauly in developing the first open-access ultrasound neuromodulation course at Stanford University.‍

 

 

 





Agenda

4:00 PM: Welcome and Introductions
4:10 PM: Tech Talk
4:45 PM: Q&A
5:00 PM: Adjourn