Next-Gen Healing: Designed by Algorithms.
Advances in intelligent computing are redefining how we discover therapeutics and engineer regenerative tissues. This talk presents two complementary, algorithm-driven approaches aimed at transforming treatments for neurological and skeletal disorders. First, we introduce a computational peptidomics pipeline that mines genomic data to identify precursor sequences encoding neuroactive peptides, which are key modulators of signal transmission that bind heptahelical receptors. Traditional peptide discovery is slow and serendipitous; our algorithms predict peptide maturation pathways, including post-translational modifications, and pair these predictions with a high-sensitivity assay capable of detecting receptor-generated second messengers such as InsPs and cAMP. This integrated strategy has yielded promising peptide-based drug candidates for Parkinson’s disease and Osteoporosis, now advancing through animal testing. Parallel to this, we present a bioengineering framework for creating biomimetic, biocompatible bone scaffolds. Using uCT images of osteoporotic bone, we design and 3D-print trabecular structures optimized for both mechanical strength and osteoconductivity, addressing limitations of current synthetic scaffolds. These engineered matrices, enhanced by the osteogenic Calcitonin Receptor Fragment Peptide, support robust osteoblast growth and functional bone formation. Together, these innovations illustrate how algorithmic design and intelligent technologies can accelerate next-generation healing, from molecular therapeutics to regenerative tissues.
Date and Time
Location
Hosts
Registration
-
Add Event to Calendar
Loading virtual attendance info...
- Contact Event Hosts
- Co-sponsored by Vishnu S. Pendyala, SJSU
Speakers
Dr. Vishnu S. Pendyala of San Jose State University
Moderator
Biography:
Vishnu S. Pendyala, Ph.D., is a faculty member in Applied Data Science and a University Senator with San Jose State University, current chair of the Santa Clara Valley Chapter of IEEE Computational Intelligence Society, Coordinator for Regions 5&6, and a Distinguished Contributor of the IEEE Computer Society. Under his leadership for 4 years as the Chair, the IEEE Computer Society SCV Chapter received the Global Outstanding Chapter for 2024. He also taught at Kyungpook National University (ranked #698 in Best Global Universities), South Korea, as a visiting scholar. As a past ACM Distinguished Speaker, researcher, and industry expert, he gave more than 100 talks and tutorial sessions in various forums such as faculty development programs, the 12th IEEE GHTC, IEEE ANTS, 12th IACC, 10th ICMC, IUCEE, 12th ACM IKDD CODS and 30th COMAD, ACM COMPUTE to audiences at venues such as Stanford University, Google, University of Wisconsin (Madison), University of Greater Manchester, University of Hawaii, Computer History Museum, Universidad de Ingeniería y Tecnología, Lima, Peru, IIT Ropar, IIIT Hyderabad, KREA, IIT Jodhpur, University of Hyderabad, IIT Indore, IIIT Bhubaneswar. Some of these talks are available on YouTube and IEEE.tv.
Dr. Pendyala is a senior member of the IEEE and ACM. He has over two decades of experience in the software industry in Silicon Valley, USA and more than 50 publications to his credit. His book, “Veracity of Big Data,” is available in several libraries, including those of MIT, Stanford, CMU, the US Congress and internationally. A few other books on AI/ML and software development that he edited are also well-received and have been included in the US Library of Congress and other reputed libraries. Dr. Pendyala taught a one-week course sponsored by the Ministry of Human Resource Development (MHRD), Government of India, under the GIAN program in 2017 to Computer Science faculty from all over the country and delivered the keynote in a similar program sponsored by AICTE, Government of India, in 2022. Dr. Pendyala served on the US government's National Science Foundation (NSF) proposal review panel in 2023 and the Canadian government’s Natural Sciences and Engineering Research Council (NSERC) in 2025 / 2026. He received the Ramanujan Memorial Gold Medal and a shield for his college at the State Math Olympiad. He also played an active role in the Computer Society of India and was the Program Secretary for its annual national convention. He has traveled widely, covering 23 countries and most states in the US and India.
Address:One Washington Sq, San Jose State University, San Jose, New York, United States, 95192-0250
Prof. Srinivas Pentyala
Next-Gen Healing: Designed by Algorithms.
Biography:
Dr. Srinivas Pentyala is the Director of Translational Research and Professor of Anesthesiology at Stony Brook University Medical Center, NY, USA. He has joint appointments in the departments of Orthopedic Surgery & Rehabilitation, Urology, Health Sciences, Physiology, and Biophysics. He is currently working on several translational and applied research projects, and his research has received funding from industry, public, and private sources. He is the recipient of “Innovative Scientist Award”, “Pride of India Gold Award”, and several “Excellence Awards” for his contributions to the field of research and education. He was awarded Stony Brook University’s highest honor – “SBU Presidents Champion Award”, along with “SBU-Wolfie Award”, “Most Influential Professor/Faculty Member” Award, “Catacosinos Cancer Scholar Award”, “Excellence in Education and Research Awards”, “CELT’s Best Teaching Professor”, and “Presidents Team Achievement Award” to name a few. He also received the “Michael Mafonte Community Service Award” – the highest honor given by Stony Brook Hospital for service to the community. He delivered around 250 invited talks all over the world and published more than 100 peer-reviewed papers along with several scientific articles. He was granted several patents, which were licensed to industry. He is the founder of a summer enrichment program in biomedical sciences, which is now in its 22nd year, where more than 3500 young students were exposed and trained in novel biomedical and bioengineering technologies. More than 300 high school, undergrad, grad, and med students, residents, fellows and post-docs worked in his research lab, and he also serves as a mentor for many junior faculty. He is the founding director of several biotech and health care companies. He serves on the advisory board of several journals, national and international biotech and health care companies, and research institutes.
Address:United States