This keynote addresses a hot and updated topic focusing on Internet of Things (IoT), considering their most relevant trends and challenges for Internet of Things. It starts with an introduction to IoT and its typical application scenarios considering different verticals. Relevant aspects considering opportunities for IoT will be addressed, considering promising verticals. The Inatel Smart Campus, an open Campus for research on IoT, experiments, and concepts and technology validation will be presented. It is a project open for companies’ participation and promotes the academy-enterprise interaction. It is a true living lab for several IoT verticals, including smart cities and smart homes. An initiative to prepare ICT professionals for new challenges regarding this new generation technologies for IoT will be presented. The communication ends with new trends and issues on Internet of Things, suggesting further research topics.