IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY LECTURES – DECEMBER 2021
Noninvasive, Targeted Drug Delivery for Neurological Diseases and Disorders
The IEEE Engineering in Medicine and Biology Society, Chicago Chapter is honored to present Dr. Muna Aryal, a promising early-career researcher in the field of ultrasound-mediated brain drug delivery.
Delivery of therapeutics into the brain is challenging because almost 100% of large and 98% of small molecules that exist in today's medicine are stopped by the special nature of brain vasculature, the blood-brain barrier (BBB) before entering into the brain tissue from the systemic blood circulation. Different methods have been used to overcome those challenges either by directly injecting drugs into the targeted brain tissue via stereotactic surgeries or by designing new pharmaceuticals, but they are invasive and non-targeted. Low intensity transcranial focused ultrasound-mediated brain drug delivery is a promising technology that can noninvasively deliver any-sized drugs with millimeter resolution to any point in the human brain with FDA-approved hardware. During this talk, Dr. Aryal will introduce three different ultrasound-based brain drug delivery techniques; the blood-brain barrier opening, the ultrasonic drug uncaging, and the ultrasonic glymphatic perturbation. She will then shed light on their applications for brain cancer treatment, neuromodulation, neuroimaging, and Alzheimer’s treatment.
Date and Time
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- Date: 14 Dec 2021
- Time: 07:00 PM to 08:00 PM
- All times are (GMT-06:00) US/Central
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- Starts 08 December 2021 08:00 PM
- Ends 14 December 2021 08:00 PM
- All times are (GMT-06:00) US/Central
- No Admission Charge
Speakers
Dr. Muna Aryal
Biography:
Dr. Muna Aryal, an assistant professor of engineering at the Loyola University of Chicago, holds a joint appointment with Stritch School of Medicine, Department of Radiation Oncology, and Division of Medical Physics within Health Science Campus. Her research lab is in Cardinal Bernardin Cancer Center at Maywood. She has a broad background in Physics and Biomedical Engineering, with specific training in ultrasound-mediated brain drug delivery. Particularly, she invented three different ways of using low-intensity transcranial focused ultrasound either alone or combining it with nanoparticles to achieve noninvasive and targeted brain treatment which can’t be done by any of the existing neuro-technologies such as stereotactic surgeries or new pharmaceuticals. Her lab focuses on advancing the ultrasound-mediated brain drug delivery techniques via basic, applied, and translational research. Her passion is expanding the world of precision medicines so that everyone receives the best-personalized ultrasound-mediated brain drug delivery plans for their neurological conditions.
Publications: https://scholar.google.com/citations?user=6-9aGVEAAAAJ&hl=en